beta amyloid

Even With Alzheimer’s Pathology, Healthy Lifestyles May Preserve Cognition

Cognitive function was better for older adults with healthy lifestyles even if they had Alzheimer’s or other dementia-related pathologies, autopsy data showed.

A 1-point increase in a healthy lifestyle score was associated with better cognitive performance proximate to death (β=0.216, P<0.001), reported Klodian Dhana, MD, PhD, of Rush University Medical Center in Chicago, and co-authors.

After adjusting for beta-amyloid load, healthy lifestyle scores remained independently associated with cognition (β=0.191, P<0.001), the researchers reported in JAMA Neurology.

Similarly, scores were independently associated with cognition after adjusting for phosphorylated tau tangle pathology (β=0.196, P<0.001) or global Alzheimer’s disease pathology (β=0.193, P<0.001). Lifestyle scores ranged from 0 to 5 points, with higher scores indicating a healthier lifestyle.

“There are a lot of epidemiological studies, including ours, supporting the role of lifestyle in dementia risk,” Dhana told MedPage Today. “However, as individuals age, there is a progressive accumulation

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Healthy Lifestyle Linked to Better Cognition in Later Life

Leading a healthy lifestyle, including regular exercise, eating fruits and vegetables, and minimal alcohol consumption, is associated with better cognitive function in older adults, new research showed.

The study, which combined longitudinal and cohort data with postmortem brain pathology reports, found that the association held even in those with Alzheimer’s disease (AD) pathology, suggesting that lifestyle factors may provide cognitive reserve and improve cognitive abilities in older age.

“While we must use caution in interpreting our findings, in part due to its cross-sectional design, these results support the role of lifestyle in providing cognitive reserve to maintain cognitive function in older adults despite the accumulation of common dementia-related brain pathologies,” Klodian Dhana, MD, of the Rush University Medical Center in Chicago, Illinois, and colleagues wrote.

The study was published online on February 5 in JAMA Neurology.

Better Cognition

The study included 586 participants (71% female) who were followed from

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