dementia related

Even With Alzheimer’s Pathology, Healthy Lifestyles May Preserve Cognition

Cognitive function was better for older adults with healthy lifestyles even if they had Alzheimer’s or other dementia-related pathologies, autopsy data showed.

A 1-point increase in a healthy lifestyle score was associated with better cognitive performance proximate to death (β=0.216, P<0.001), reported Klodian Dhana, MD, PhD, of Rush University Medical Center in Chicago, and co-authors.

After adjusting for beta-amyloid load, healthy lifestyle scores remained independently associated with cognition (β=0.191, P<0.001), the researchers reported in JAMA Neurology.

Similarly, scores were independently associated with cognition after adjusting for phosphorylated tau tangle pathology (β=0.196, P<0.001) or global Alzheimer’s disease pathology (β=0.193, P<0.001). Lifestyle scores ranged from 0 to 5 points, with higher scores indicating a healthier lifestyle.

“There are a lot of epidemiological studies, including ours, supporting the role of lifestyle in dementia risk,” Dhana told MedPage Today. “However, as individuals age, there is a progressive accumulation

Read the rest